Philipp. Sci. Lett. 2014 7 (1) 245-274
available online: June 25, 2014
Email Address: firstname.lastname@example.org
Received: October 21, 2013
Revised: March 8, 2014
Accepted: March 20, 2014
An important task in genetics research is to be able to generate a set of candidate genes causal towards expression of a particular trait. In this paper, a partial regression coefficient analysis framework to infer candidate genes causal to a trait, particularly for recombinant inbred lines, is proposed. The framework integrates marker data, quantitative trait loci data, phenotypic data, and gene expression and location data to generate set of candidate genes. The framework was applied to infer candidate causal genes to salt tolerance in rice. Results suggest 91 genes to be potentially causal to salt tolerance in rice. Review of the literature substantiated the results in mentioning the role of genes related to cell wall and membrane-related function, signal transduction, and gene expression-related functions to salt tolerance in rice.